Bacillus megaterium.
Corynebacterium glutamicum.
Alcaligenes eutrophus.

Bt cotton is a genetically modified organism (GMO) or genetically modified pest resistant plant cotton variety, which produces an insecticide activity to bollworm. Strains of the bacterium Bacillus thuringiensis produce over 200 different Bt toxins, each harmful to different insects. Most Bt toxins are insecticidal to the larvae of moths and butterflies, beetles, cotton bollworms and gat flies but are harmless to other forms of life. The genes are encoded for toxic crystals in the Cry group of endotoxin. When insects attack and eat the cotton plant the Cry toxins are dissolved in the insect's stomach. The epithelial membranes of the gut block certain vital nutrients thereby sufficient regulation of potassium ions are lost in the insects and results in the death of epithelial cells in the intestine membrane which leads to the death of the larvae.

Spirulina, Chlorella and Chlamydomonas.

Secondary metabolites are those which are not required for the vital life process of microbes, but have value added nature, this includes antibiotics e.g. -Amphotericin-B (Streptomyces nodosus) and Penicillin (Penicillium chryosogenum).

Upstream process:
All the process before starting of the fermenter such as sterilization of the fermenter, preparation and sterilization of culture medium and growth of the suitable inoculum are called upstream process.
Downstream process:
All the process after the fermentation process is known as the downstream process. This process includes distillation, centrifuging, filtration and solvent extraction. Mostly this process involves the purification of the desired product.