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Published on: 25/10/2025
Download CBSE Class 12th Standard CBSE Biology question papers, sample papers, important questions, and previous year solved papers in PDF format. Get free study materials, NCERT solutions, and exam preparation resources for Class 12th Standard CBSE Biology
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1.
Make a table showing blood groups possible in offsprings and not possible in the following crosses.
1. \(O\times O\) 2. \(O\times A\quad \) 3.\(O\times B\) 4. \(O\times AB\) 5. \(A\times A\) 6.\(A\times B\) 7. \(A\times AB\) 8. \(B\times B\) 9. \(B\times AB\) 10. \(AB\times AB\).
2.
(ii) Explain a monohybrid cross, taking seed coat colour as a trait in pisum sativum. Work out the cross upto F2 generation.
(ii) State the laws of inheritance that can be derived from such a cross.
(iii) What is the phenotypic ratio in a dihybrid cross?
3.
Given below is the representation of amino acid composition of the relevant translated portion of \(\beta \)-chain of hemoglobin, related to the shape of human red blood cells
(a) Is this representation indicating a normal human or a sufferer from certain genetic disease? Give reason in support of your answer.
(b) What difference would be noticed in the phenotype of the normal and the sufferer related to this gene?
(c) Who are likely to suffer more from the defect related to the gene represented - the males, the females or both males and females equally? And why?
4.
Replication was allowed to take place in the presence of radioactive deoxynucleotide precursors in E.coli that was mutant for DNA ligase.
Newly synthesised radioactive DNA was purified and strands were separated by denaturation.
These were centrifuged using density gradient centrifugation.Which of the following would be a correct result?

5.
What are the following of mRNA and tRNA ?What anticodons will be required to recognize the following codons?
(i)AAU
(ii)CGA
(iii)UAC
(iv)GCA
6.
List three main differences between DNA and RNA
7.
Study the given pedigree chart showing the pattern of blood group inheritance in a family.

(a) Give the genotype of the following :
(i) Parents
(ii) The individual 'X' in second generation
(b) State the possible blood groups of the individual 'Y' in the third generation.
(c) How does the inheritance of this blood group explain codominance?
8.
Study the figures given below and answer the question
Identify in which of the crosses the strength of linkage between the genes is higher. Give reasons in support of your answer
9.
Explain when is a genetic code said to be
(i) Degenerate (ii) Universal
10.
Give an example of each type.
(i) Female XX with Male XO
(ii) Female ZW with Male ZZ.
1.
| S.NO | Blood groups of parents | Blood groups possible in children | Blood groups not possible in children |
| 1 | \(O\times O\) | O | A, B, AB |
| 2 | \(O\times A\quad \) | O, A | B, AB |
| 3 | \(O\times B\) | O, B | A, AB |
| 4 | \(O\times AB\) | A, B | O, AB |
| 5 | \(A\times A\) | O, A, B, AB | None |
| 6 | \(A\times B\) | O, A, B, AB | None |
| 7 | \(A\times AB\) | A, B | O |
| 8 | \(B\times B\) | O, B | A, AB |
| 9 | \(B\times AB\) | A, B, AB | O |
| 10 | \(AB\times AB\) | A, B, AB | O |
2.
(i) In a monohybrid cross, when homozygous dominant and honozygous recessive parents arc crossed, F1- hybrid would be heterozygous for the trait and would express the dominant allele.

(ii) The hybrid is heterozygous containing both alternative alleles (Y and y) but only one trait, i.e. yellow colour appeared and green colour trait is suppressed in F1 -generation.
This shows that yellow seed colour is dominant over the green seed colour trait. This explains Mendel's law of dominance.
(iii) Phenotypic ralio in Fgeneration, Yellow seeds :Green seeds (3 : 1) in monohybrid cross andin dihybrid cross 9:3 :3: 1.
3.
(a) This representation (HbA peptide) indicates a normal human, because the glutamic acid in the sixth position is not substituted by Valine
(b) The sufferer's RBCs become elongated and sickle shaped as compared to the normal biconcave RBCs.
(c) Both males and females are likely to suffer from the disease equally, as this is not a sex linked disease. It is an autosomal linked recessive trait.
4.
1. In the given case, as E.coli is a mutant for DNA ligase, it will result in no further joining of Okazaki fragments on lagging strand.
2. This will ultimately result into the formation of both high molecular weight fragments (on leading strands) and low molecular weight fragments (on lagging strand). Hence, only the graph (a) could be the appropriate result after centrifugation.
5.
mRna caries a message from DNA to ribosome sin the form of sequence of triplet codes.It acts as a plateform where protein synthesis takes place.tRNA transfer aminoacids to protein synthesizing apparatus.mRNA possess codons and tRNA possess anticodons.The anticodons are---(i)UUA,(ii)GUC,(iii)AUA,(iv)CGU
6.
Differences between DNA and RNA
| DNA | RNA |
| 1) It is a double-stranded helical structure and genetic material of most of animals and plants 2) Deoxyribose is the sugar 3) Thymine is the pyrimidine |
1) It is a single-stranded molecule and genetic material of certain viruses 2) Ribose is the sugar in RNA 3) Uracil is the pyrimidine in the RNA |
7.
(a) (i) Father \(I(I^{ \wedge }i)\) and mother \(I(I^{ B }i)\)
(ii) \(I^{ \wedge }I^{ \wedge }\quad or\quad I^{ \wedge }i\) or u
(b) Y can be of blood group A or 0
(c) - The gene for blood group trait has three alleles, lA, IB and i
-\(I^{ A }\) and \(I^{ B }\) are not only dominant over but are also codominant, i.e.
both of them express themselves in the presence of the other, in producing the phenotype, blood group AB.
8.
Cross A, because they are tightly linked I due to close physical association I they are closely located
9.
The differences between unambiguous and universal genetic codes are as follows
| Unambiguous | Universal |
| In genetic code, one codon codes for only one amino acid hence, it is unambiguous | The genetic code is universal.i.e. each codon codes for same amino acid in all organisms |
(ii) The differences between degenerate and initiator codes are as follows
| Degenerate | Initiator |
| Some amino acids are coded by more than one codon, hence the code is degenerate, e.g. serine, leucine, arginine are encoded by 6 codons. | These codons act as start signal for translation. e.g. AUG acts as initiator codon and it codes for methionine |
10.
(i) The type of sex-determination mechanism in which female XX with male XO is male heterogamety, e.g. grasshopper.
(ii) The type of sex-determination mechanism shown in female ZW with male ZZ is female heterogamety, e.g. birds.
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