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Published on: 05/10/2019
Principles of Inheritance and Variation
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1.
Explain Monohybrid cross.
2.
What exactly is dominance? Why are some alleles dominant and some recessive?
3.
State the law that Mendel proposed on the basis of such a cross.
4.
Haemophilia and sickle-cell anaemia are blood related Mendelian disorders. Yet, they differ in their pattern of inheritance. Explain the difference.
5.
Describe the mechanism of pattern of inheritance of ABO blood groups in humans.
6.
(a) Explain the genetic basis of ABO blood groups in human population.
(b) How do ABO blood groups explain the phenomena of dominace and codominance?
7.
Differentiate between the following:
(a) Polgenic inheritance and Pleiotropy
(b) Dominance, Codominance and Incomplete dominance
8.
(a) State the cause and symptoms of Down's syndrome. Name and explain the event responsible for causing this syndrome.
(b) Haemophilia and Thalassemia are both examples of Mendelian disorders, but show differences in their inheritance pattern. Explain how.
1.
Monohybrid cross. It is a cross in which only one character is considered at a time. In a cross between tall and dwarf plant, the size of stem is considered. Mendel made a cross between pure tall
(TT) and a pure dwarf (tt) pea plant as follows:
Mendel selected a tall pea plant represented by genes (TT)and a dwarf pea plant represented by genes (tt). Pea plant is self pollinating. He removed the anthers of tall plant and stigma of dwarf plant, deposited pollen grains of dwarf plant on the stigma of tall plant and obtained seeds.
When the seeds were placed in the soil and allowed to grow he obtained only tall plant (Tt), although he was expecting the plants of an intermediate size. These plants were labelled as plants of First filial generation (\(F_{ 1 }\)
generation). In \(F_{ 1 }\) generation all plants were tall because the character tall is dominant over the dwarf.
He allowed the plants ofY~enerl:!tion to self pollinate. Gametes formed by meiosis contained only
2.
Dominance:
Every gene contains the information to express a particular trait.
In a diploid organism, there are two alternate forms of a gene, or a pair of alleles.
The two alleles may be similar (homo-zygous) or may be different (heterozygous).
One of them may be different due to some changes that it has undergone, which modify the information of that particular allele.
The phenotype will be dependent on the original unmodified allele.
3.
\((i)W-I^{ \wedge }I^{ \wedge }\quad or\quad I^{ \wedge }i;\quad X-ii\\ Y-B-\quad group;Z-AB-group\)
(ii)
(b) Dominance·
It is the phenomenon in which one allele of a gene expresses itself and suppresses the expression of the other (recessive) allele of the same gene, when they are present together in a hybrid.
The hybrid resembles one of the parents.
Codominance:
It is the phenomenon in which two alleles of a gene are equally dominant and express themselves in the presence of the other.
The hybrid shows characters of both the parents.
Incomplete dominance:
It is the phenomenon in which neither of the two alleles of a gene is completely dominant over the other.
The hybrid is intermediate between the two parents.
(iii) Y The allele \(I^{ B }\) dominant over i and hence the phenotype is B-group. Z : The alleles \(I^{ A }\) and \(I^{ B }\) are codominant and both express themselves and the phenotype is AB- group.
4.
Symptoms of Haemophilia:
1.Since a protein necessary for blood clotting is not formed, the blood does not clot and there is non-stop bleeding in case of an injury in the afflicted individual. Symptoms of sickle-cell anaemia.
2. The RBCs become sickle-shaped.
3. The oxygen transport to the tissues is impaired.
Differences
| Haemophilia | sickle-cell anaemia |
| 1. It is due to a defective recessive allele present on the X-chromosomes,i.e. it is a sex-linked disorder. 2. More males than females are affected 3. The female parent passes on the disorder to male progency but father never passes it on to the male progency. |
1.It is due to point mutation i.e. a single base pair change leading to change acid i.e. it is an autosomal disorder. 2. Both males and females are affected . 3. The female parent passes on the disorder to male or female progency in equal frequency also passes on the disorder to male and female progency. |
5.
(i) The gene for blood group character exists in three allelic forms, lA, IB, and i.
(ii) It is the phenomenon of multiple allelism, as there are more than two allelic forms of a gene.
Any individual carries two of the three alleles.
(iii) The allele \(I^{ A }\) codes for glycoprotein A and the allele IBcodes for glycoprotein B, that are found on the surface of RBCs; the allele i does not produce any glycoprotein.
(iv) The allele \(I^{ A }\) is dominant over i and IB' is also dominant over i.
(v) When the alleles \(I^{ A }\) and \(I^{ B }\) are together. they are equally dominant and both the glycoproteins A and B are produced, making the blood group AB; this phenomenon, where both the alleles are equally dominant, is known as codominance.
(vi) The blood group is determined by the glycoprotein(s) on the RBCs.
(vii) There are six genotypes and four phenotypes as given in table.
| Genotypes (s) | Blood group |
| \(I^{ A }\quad I^{ A }\quad orI^{ \wedge }i\) | A |
| \(I^{ B }\quad I^{ B }\quad orI^{ B }i\) | B |
| \(I^{ A }\quad I^{ B }\) | AB |
| ii | O |
6.
(i) The gene for blood group character exists in three allelic forms, lA, IB, and i.
(ii) It is the phenomenon of multiple allelism, as there are more than two allelic forms of a gene.
(iii) Any individual carries two of the three alleles.
(iv) The allele \(I^{ A }\) codes for glycoprotein A and the allele IBcodes for glycoprotein B, that are found on the surface of RBCs; the allele i does not produce any glycoprotein.
(v) The allele \(I^{ A }\) is dominant over i and IB' is also dominant over i.
(vi) When the alleles \(I^{ A }\) and \(I^{ B }\) are together. they are equally dominant and both the glycoproteins A and B are produced, making the blood group AB; this phenomenon, where both the alleles are equally dominant, is known as codominance.
(vii) The blood group is determined by the glycoprotein(s) on the RBCs.
(viii) There are six genotypes and four phenotypes as given in table.
| Genotypes (s) | Blood group |
| \(I^{ A }\quad I^{ A }\quad orI^{ \wedge }i\) | A |
| \(I^{ B }\quad I^{ B }\quad orI^{ B }i\) | B |
| \(I^{ A }\quad I^{ B }\) | AB |
| ii | O |
7.
(a)
| Polygenic inheritance | Pleiotropy |
| It is a phenomenon in which a character is controlled by two or more genes. There is gradation in the phenotypes. |
It is a phenomenon where a single gene controls more than one phenotypic effect. There is no gradation of the phenotype. |
(b) Dominance·
It is the phenomenon in which one allele of a gene expresses itself and suppresses the expression of the other (recessive) allele of the same gene, when they are present together in a hybrid.
The hybrid resembles one of the parents.
Codominance:
It is the phenomenon in which two alleles of a gene are equally dominant and express themselves in the presence of the other.
The hybrid shows characters of both the parents.
Incomplete dominance:
It is the phenomenon in which neither of the two alleles of a gene is completely dominant over the other.
The hybrid is intermediate between the two parents.
8.
(a) It is due to trisomy of 21st chromosome.
The symptoms include
Short stature and small round head with a flat back.
Rartially open mouth with furrowed tongue.
Broad, flat face with slanting eyes.
Broad palm with characteristic palm crease.
Retarded physical, mental and psychomotor development.
It is caused by the non-segregation of the 21st chromosomes during meiosis in the gamete formation; when such an ovum is fertilised by a normal sperm, the individual comes to possess three copies (trisomy) of 21st chromosome.
(b)
| Haemophilia | Thalassemia |
| The gene for haemophilia is present on the X-chromosome. A female passes the X-chromosome to the male offspring while the male parent passes it to the female progency. It appears more in males than in females. |
The gene is present on the autosomes. Since it is autosomal, both the parents can pass it on to the male and female offspring with equal chances. It occurs in equal frequency among male and females. |
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